Synthesis of saframycins. XI. Synthetic studies toward a total synthesis of safracin A

Article abstract of DOI:10.1016/0040-4020(95)00437-D

A synthetic strategy for the preparation of isoquinolinequinone antibiotic safracin A (1a) is outlined. Our initial strategy for the construction of the ABC ring was based on a retrosynthetic analysis. Conversion of 5 in five steps to the imide 16 was fol