Acyliminothiadiazoline derivatives: New, highly potent, and orally active angiotensin II receptor antagonists

DOI: 10.1016/S0960-894X(96)00250-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1469 - 1474 (1996)

Update date:2022-08-06

Topics:

Authors:

Hirata, Terukage

Nomiyama, Jun

Sakae, Nobuya

Nishimura, Kouji

Yokomoto, Masaharu

Inoue, Satoshi

Tamura, Koichi

Okuhira, Masayasu

Amano, Hirotaka

Nagao, Yoshimitsu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00250-8

Syntheses and pharmacological properties of a new series of acyliminothiadiazoline derivatives 1 are described. These compounds exhibited angiotensin II receptor antagonistic activities in vitro and in vivo. Among them, the compound 1g (KRH-594) showed the strongest antihypertensive action in renal hypertensive rats after oral administration, and its oral bioavailability in dogs was also found to be high (73%).

Full text of DOI:10.1016/S0960-894X(96)00250-8

Products guided by the article

Product name:2-trifluoroacetylimino-5-ethyl-3-(2'-cyanobiphenyl-4-yl)methyl-1,3,4-thiadiazoline

Cas No:169328-26-1

R&D Labs maybe for 169328-26-1

Sinoway International (Jiangsu) Co., Ltd.

Contact:+86-25-86630167

Address:17 Beijing Road (West), Nanjing, China
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.

Contact:+86 532 80861829

Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
New Forms

Contact:+31-24-3886056

Address:Binderskampweg 29 Unit 36
jintan yufan Medicine Raw materials Co.,Ltd.(expird)

Contact:86-519-82808282

Address:6th,Jincheng Huangzhuang
Sino-Japan Chemical Co., Ltd.

website:http://www.sjc.com.tw

Contact:(886) 2-2396-6223

Address:14Fl., No. 99. Sec. 2, Jen Ai Road

Relevant to this article

Enantiomerically Pure 6-Substituted 2-Oxo-cyclohexanecarboxylates by Conjugate Addition of Cuprates to Asymmetric Shielded 2-Oxo-cyclohexenecarboxylates

Doi:10.1016/0040-4020(95)00676-Y
(1995)
Synthesis and Reactions of Alkali Metal Derivatives of the Ph4P2N4S2(2-) Dianion: X-ray Structure of Cp(*)Rh(η3-Ph4P2N4S2-N,S,S')

Doi:10.1021/ic00124a019
(1995)
Enantioselective total synthesis of gracilins B and C using catalytic asymmetric Diels-Alder methodology

Doi:10.1021/ja00142a051
(1995)
Synthese et Reactions S_RN1 en Serie 3-Nitroimidazo<1,2-a>pyrimidine

Doi:10.1016/0040-4020(95)00539-K
(1995)
Trifluoromethyl thiolsulphonates.

Doi:10.1038/214478a0
(1967)
2-Benzyloxymethyl-5-(tributylstannyl)tetrazole. A reagent for the preparation of 5-aryl- and 5-heteroaryl-1H-tetrazoles via the Stille reaction

Doi:10.1016/S0040-4039(00)00268-9
(2000)

Article Doi