Acyliminothiadiazoline derivatives: New, highly potent, and orally active angiotensin II receptor antagonists

DOI: 10.1016/S0960-894X(96)00250-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1469 - 1474 (1996)

Update date:2022-08-06

Topics:

Authors:

Hirata, Terukage

Nomiyama, Jun

Sakae, Nobuya

Nishimura, Kouji

Yokomoto, Masaharu

Inoue, Satoshi

Tamura, Koichi

Okuhira, Masayasu

Amano, Hirotaka

Nagao, Yoshimitsu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00250-8

Syntheses and pharmacological properties of a new series of acyliminothiadiazoline derivatives 1 are described. These compounds exhibited angiotensin II receptor antagonistic activities in vitro and in vivo. Among them, the compound 1g (KRH-594) showed the strongest antihypertensive action in renal hypertensive rats after oral administration, and its oral bioavailability in dogs was also found to be high (73%).

Full text of DOI:10.1016/S0960-894X(96)00250-8

Products guided by the article

Product name:2-trifluoroacetylimino-5-ethyl-3-(2'-cyanobiphenyl-4-yl)methyl-1,3,4-thiadiazoline

Cas No:169328-26-1

R&D Labs maybe for 169328-26-1

Alway Chem, China

website:http://www.alwaychem.com

Contact:+86-532-8586-4000, 8586-5000

Address:NO.51, TAIPING ROAD, QINGDAO, CHINA. 266001
Tosta Enterprise Co., Ltd.

Contact:+86-134-5286-9121

Address:Add: Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong,
Phytomarker Ltd.(expird)

Contact:+86-22-26358246

Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
HangZhou HuaYe Chemical Technology Co.,Ltd

Contact:+86-13505815007

Address:hangzhou
ANGCHEN BRIGHTCHEM CO., LTD

website:http://www.angchenchem.com

Contact:+86-510-88302099 82327577

Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China

Relevant to this article

Enantiomerically Pure 6-Substituted 2-Oxo-cyclohexanecarboxylates by Conjugate Addition of Cuprates to Asymmetric Shielded 2-Oxo-cyclohexenecarboxylates

Doi:10.1016/0040-4020(95)00676-Y
(1995)
Synthesis and Reactions of Alkali Metal Derivatives of the Ph4P2N4S2(2-) Dianion: X-ray Structure of Cp(*)Rh(η3-Ph4P2N4S2-N,S,S')

Doi:10.1021/ic00124a019
(1995)
Enantioselective total synthesis of gracilins B and C using catalytic asymmetric Diels-Alder methodology

Doi:10.1021/ja00142a051
(1995)
Synthese et Reactions S_RN1 en Serie 3-Nitroimidazo<1,2-a>pyrimidine

Doi:10.1016/0040-4020(95)00539-K
(1995)
Trifluoromethyl thiolsulphonates.

Doi:10.1038/214478a0
(1967)
2-Benzyloxymethyl-5-(tributylstannyl)tetrazole. A reagent for the preparation of 5-aryl- and 5-heteroaryl-1H-tetrazoles via the Stille reaction

Doi:10.1016/S0040-4039(00)00268-9
(2000)

Article Doi