Antihyperglycemic N-sulfonyl-1a,2,6,6a-tetrahydro-1H,4H- [1,3]dioxepino[5,6-b]azirines: Synthesis, X-ray structure analysis, conformational behavior, quantitative structure-property relationships, and quantitative structure-activity relationships

Article abstract of DOI:10.1021/jm00016a006

A series of 1-sulfonyl-1a,2,6,6a-tetrahydro-1H,4H-[1,3]dioxepino[5,6- b]azirines, 4, has been synthesized and evaluated for its effects on blood glucose-decreasing activity. These derivatives were prepared from 4,7- dihydro-1,3-dioxepins 1 via vic(acylami