Total synthesis of (+/-)-phosphonothrixin, a novel herbicidal antibiotic containing C-P bond.

Article abstract of DOI:10.7164/antibiotics.48.1134

Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. ST-888, with a unique structure possessing a C-P bond and an isoprene unit. The total synthesis of this antibiotic was accomplished from methyl (bromomethyl)acrylate in six steps.