Lipase-catalyzed enantiosynthesis of (R)- and (S)-2- [benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2- yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate (NZ 105)

DOI: 10.1248/cpb.43.1251

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1251 - 1253 (1995)

Update date:2022-08-02

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Authors:

Ebiike Ebiike

Yamazaki

Achiwa Achiwa

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Article abstract of DOI:10.1248/cpb.43.1251

Homochiral 4-Aryl-1,4-dihydropyridine-5-phosphate (NZ 105) was synthesized from the racemic materials. The enantioselective hydrolysis by lipase catalyst was smoothly proceeded and optically active carboxylic acid was converted into optically active medic

Full text of DOI:10.1248/cpb.43.1251

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Product name:(R)-5-(5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid propionyloxymethyl ester

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