Bioorganic and Medicinal Chemistry Letters p. 1 - 6 (1997)
Update date:2022-08-05
Topics:
Musso, David L.
Mehta, Nariman B.
Soroko, Francis E.
A series of 2-amino-1-phenyl-1-propanols that are structurally related to known metabolites of bupropion, 1 (Wellbutrin) were synthesized and evaluated as potential anticonvulsants. The (R*,R*)-2-tert-butylamino-1-(3-trifluoromethylphenyl) propanol 20 had an ED50 of 16.5 ± 2.8 mg/kg ip in mice in the maximal electroshock screen and was chosen for further evaluation.
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