Synthesis of 'Retro-Inverso" Peptide Nucleic Acids: 2. Oligomerization and Stability

DOI: 10.1016/0040-4039(95)01375-R

Source and publish data:

Tetrahedron Letters p. 6941 - 6944 (1995)

Update date:2022-08-03

Topics:

Authors:

Krotz, Achim H.

Buchardt, Ole

Nielsen, Peter E.

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Article abstract of DOI:10.1016/0040-4039(95)01375-R

Novel PNA oligomers containing an N-(aminomethyl) β-alanine backbone ('retroinverso' PNA) were prepared via blocksynthesis or via a combination of solution and solid-phase chemistry.The half-life time of the unprotected N terminus is 38 h at pH 7.0 (20 deg C) and is pH dependent.

Full text of DOI:10.1016/0040-4039(95)01375-R

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