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The Synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen

DOI: 10.1016/0040-4020(95)00710-P

Source and publish data:

Tetrahedron p. 11465 - 11472 (1995)

Update date:2022-07-29

Topics:

Authors:

Prager, Rolf H.Prager, Rolf H.

Schafer, KarlSchafer, Karl

Hamon, David P. G.Hamon, David P. G.

Massy-Westropp, Ralph A.Massy-Westropp, Ralph A.

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Article abstract of DOI:10.1016/0040-4020(95)00710-P

2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide.The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen.Only the latter showed activity as a specific GABAB antagonist.

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Full text of DOI:10.1016/0040-4020(95)00710-P

Products guided by the article

Product name:4-Nitro-benzoic acid (S)-2-(4-chloro-phenyl)-oxiranylmethyl ester

Cas No:172789-03-6

172789-03-6

R&D Labs maybe for 172789-03-6

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