The Synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen

DOI: 10.1016/0040-4020(95)00710-P

Source and publish data:

Tetrahedron p. 11465 - 11472 (1995)

Update date:2022-07-29

Topics:

Authors:

Prager, Rolf H.

Schafer, Karl

Hamon, David P. G.

Massy-Westropp, Ralph A.

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Article abstract of DOI:10.1016/0040-4020(95)00710-P

2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide.The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen.Only the latter showed activity as a specific GABA_B antagonist.

Full text of DOI:10.1016/0040-4020(95)00710-P

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