Tetrahedron p. 11465 - 11472 (1995)
Update date:2022-07-29
Topics:
Prager, Rolf H.
Schafer, Karl
Hamon, David P. G.
Massy-Westropp, Ralph A.
2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide.The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen.Only the latter showed activity as a specific GABAB antagonist.
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(1995)
