Lactam-conformationally restricted analogs of N(α)-arylsulfonyl arginine amide: Design, synthesis and inhibitory activity toward thrombin and related enzymes

DOI: 10.1248/cpb.43.1683

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1683 - 1691 (1995)

Update date:2022-08-04

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Authors:

Okayama Okayama

Seki Seki

Ito Ito

Takeshima

Hagiwara

Morikawa

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Article abstract of DOI:10.1248/cpb.43.1683

Three new lactam-conformationally restricted arginine derivatives, 1- butyl-3-(6,7-dimethoxy-2-naphthylsulfonyl)-3-(3-guanidinopropyl)-substituted γ-, δ-, and ε-lactams (2-4), were synthesized on the basis of backbone modification of the lead structure, 6

Full text of DOI:10.1248/cpb.43.1683

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