A highly diastereoselective synthesis of trans-3,4-(difluoromethano)glutamic acid

Article abstract of DOI:10.1016/0040-4020(95)00870-E

Reaction of enantiomerically pure N-(4'-bromo-4',4'-difluorocrotonoyl)oxazolidinone 5 with lithium enolate of N-diphenylmethylideneglycinate 6 in DMF proceeded in highly diastereoselective manner to give trans-disubstituted gem-difluorocyclopropane 7, which was readily converted to the 3,4-(difluoromethano)glutamic acid 4.