Novel nucleosides via intramolecular functionalization of 2,2'-anhydrouridine derivatives

Article abstract of DOI:10.1016/0040-4039(96)00227-4

The generation of novel ribonucleoside analogues derived from 2,2'-anhydrouridines by a 3'-hydroxyl directed intramolecular nucleophilic substitution of the 2'-position is described. The methodology allows for the efficient, regio- and stereoselective elaboration of the 2'-position, often under exceptionally mild reaction conditions.