4′-O-[2-(2-fluoromalonyl)]-L-tyrosine: A phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides

DOI: 10.1021/jm950621g

Source and publish data:

Journal of Medicinal Chemistry p. 1021 - 1027 (1996)

Update date:2022-07-30

Topics:

Authors:

Burke Jr., Terrence R.

Ye, Bin Ye, Bin

Akamatsu, Miki

Ford Jr., Harry

Yan, Xinjian

Kole, Hemanta K.

Wolf, Gert

Shoelson, Steven E.

Roller, Peter P.

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Article abstract of DOI:10.1021/jm950621g

Development of phosphotyrosyl (pTyr) mimetics which are stable to protein-tyrosine phosphatases (PTPs), yet can retain biological potency when incorporated into peptides, is an active area of drug development. Since a majority of pTyr mimetics derive thei

Full text of DOI:10.1021/jm950621g

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