β-Methanesulfonyl-L-valine as a novel, unnatural amino acid surrogate for P2 in the design of HIV protease inhibitors

DOI: 10.1016/0960-894X(96)00086-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 585 - 588 (1996)

Update date:2022-07-30

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Authors:

Park, Chihyo

Choi, Hoil

Son, Young-Chan

Lee, Chang Sun

Choy, Nakyen

Koh, Jong Sung

Lee, Tae Gyu

Kwon, Young Do

Kim, Sung Chun

Yoon, Heungsik

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Article abstract of DOI:10.1016/0960-894X(96)00086-8

β-Methanesulfonyl-L-valine as a surrogate for asparagine and valine was designed, synthesized, and characterized. A representative compound 1 showed IC₅₀ of 4.9 nM.

Full text of DOI:10.1016/0960-894X(96)00086-8

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