Enantioselective Synthesis of trans-Whisky Lactone by Using Newly Developed Asymmetric Ring Expansion Reaction of Oxetane as a Key Step

Article abstract of DOI:10.1246/cl.1995.1027

A mixture of optically active 3-substituted cis- and trans-tetrahydrofuran-2-carboxylates which was prepared in one step from readily available (+/-)-2-alkynyloxetane, was converted into trans-whisky lactone (2) in a straightforward manner.