
Chemistry Letters p. 185 - 186 (1996)
Update date:2022-08-04
Topics:
Murakami, Masahiro
Ito, Hajime
Ito, Yoshihiko
Preparation of a 13C-labeled isocyanide and its application to the total synthesis of [2-13C]D-ribo-C18-phytosphingosine are described. The synthesis of the labeled phytosphingosine is based on the use of the isocyanide as a 13CH-NH2 precursor in the SmI2-mediated three-component coupling reaction, wherein regio- and stereoselective incorporation of a 13C nuclide in the carbon skeleton is achieved.
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