Stereoselective conjugate addition of lithium and titanium enolates to γ - Alkoxy enones

DOI: 10.1016/0040-4020(96)00028-2

Source and publish data:

Tetrahedron p. 3497 - 3508 (1996)

Update date:2022-09-26

Topics:

Authors:

Bernardi, Anna

Marchionni, Chiara

Novo, Barbara

Karamfilova, Katia

Potenza, Donatella

Scolastico, Carlo

Roversi, Pietro

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Article abstract of DOI:10.1016/0040-4020(96)00028-2

The addition of titanium and lithium enolates 1 and 2 to γ-alkoxy enone 4 occurs in good yield with good stereoselectivities. 3,4 syn - 2,3 syn adducts 7 are obtained starting from the lithium enolate 2, whereas the 3,4 syn - 2,3 anti isomers 9 are formed using the titanium enolate 1. The levels of selectivity vary with the nature of the oxygen protecting group.

Full text of DOI:10.1016/0040-4020(96)00028-2

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