A short, enantiospecific synthesis of a protected seco acid precursor to (R,R)-(-) pyrenophorin

Article abstract of DOI:10.1016/0040-4039(96)00323-1

Described herein is a four-step enantiospecific synthesis of a protected seco acid precursor of (R,R)-(-)-pyrenophorin in 23% yield from a chiral β-ketoester 3, which can be prepared in one step from ethyl acetoacetate by a standard procedure.