
Tetrahedron Letters p. 3911 - 3914 (1996)
Update date:2022-08-03
Topics:
Malpass
Hemmings
Wallis
Synthetic approaches are described leading to homoepibatidine and bis- homoepibatidine which are based, respectively, on the tropane (8- azabicyclo[3.2.1]octane) and homotropane (9-azabicyclo-[4 2.1]nonane) ring systems. Epoxy- tropanes and -homotropanes (which are readily available from simple cyclic dienes) are convenient precursors for the azabicyclic alkenes needed for the key reductive coupling with pyridine derivatives.
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