Synthetic study on curacin A: A novel antimitotic agent from the cyanobacterium Lyngbya majuscula

Article abstract of DOI:10.1016/0040-4020(96)00899-X

Curacin A (1), a novel antimitotic agent, was synthesized in a highly stero-controlled manner. The four stereoisomers of a partial structure at the thiazoline moiety, 2 were also synthesized to aid in elucidation of the absolute configurations of three chiral centers in curacin A. The effects of porcine brain tubulin assembly of several synthetic compounds related to curacin A were examined.