Synthesis of E-selectin inhibitors: Use of an aryl-cyclohexyl ether as a disaccharide scaffold

Article abstract of DOI:10.1016/0040-4039(96)00713-7

A series of potential E-selectin antagonists were designed and synthesized based on the bound conformation of sLe(x), as well as the functional group requirements for anti-adhesion activity. A non carbohydrate scaffolding using an aryl-cyclohexyl ether which can orient the critical acid and fucose residues in appropriate positions has been investigated. The inhibitory activity of members of this series suggests the feasibility of non- carbohydrate E-selectin antagonists.