Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative

DOI: 10.1016/S0960-894X(99)00549-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3123 - 3126 (1999)

Update date:2022-08-04

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Authors:

Yoshida, Yoshiki

Matsuda, Keiji

Sasaki, Hiroshi

Matsumoto, Yoshimi

Matsumoto, Satoru

Takasugi, Hisashi

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Article abstract of DOI:10.1016/S0960-894X(99)00549-1

The synthesis and anti-Helicobacter pylori activity of a novel cephem derivative FR182024 (1) are described. FR182024 having a (5-methyl-1,3,4-thiadiazol-2-yl)-thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have extremely potent in vitro anti-H.pylori activity, superior therapeutic efficacy to AMPC and CAM, and low potential for causing diarrhea.

Full text of DOI:10.1016/S0960-894X(99)00549-1

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Product name:benzhydryl 7β-(2-phenylacetamido)-3-(5-methyl-1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylate

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