Bioorganic and Medicinal Chemistry Letters p. 3123 - 3126 (1999)
Update date:2022-08-04
Topics:
Yoshida, Yoshiki
Matsuda, Keiji
Sasaki, Hiroshi
Matsumoto, Yoshimi
Matsumoto, Satoru
Takasugi, Hisashi
The synthesis and anti-Helicobacter pylori activity of a novel cephem derivative FR182024 (1) are described. FR182024 having a (5-methyl-1,3,4-thiadiazol-2-yl)-thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have extremely potent in vitro anti-H.pylori activity, superior therapeutic efficacy to AMPC and CAM, and low potential for causing diarrhea.
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