Bioorganic and Medicinal Chemistry Letters p. 2657 - 2662 (1996)
Update date:2022-08-03
Topics:
De Paulis, Tomas
Trivedi, Bakula L.
Zhang, Zhang-Jin
Schmidt, Dennis E.
Ebert, Michael H.
Hewlett, William A.
TRIZAC is one of the most potent 5-HT-3 receptor antagonist reported to date, having 20-fold higher affinity than (S)-5-iodozacopride. This high affinity (K(i) 0.05 ± 0.01 nM) and a moderate apparent lipophilicity (log P(app) 2.12) makes TRIZAC a promising ligand for studying 5-HT-3 receptors.
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Doi:10.1246/bcsj.69.1727
(1996)Doi:10.1021/jacs.8b05240
(2018)Doi:10.1021/jacs.0c02221
(2020)Doi:10.1021/jo960488f
(1996)Doi:10.1016/j.ica.2020.119594
(2020)Doi:10.1007/BF01169352
(1996)
