(S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)b enzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor

DOI: 10.1016/S0960-894X(96)00497-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2657 - 2662 (1996)

Update date:2022-08-03

Topics:

Authors:

De Paulis, Tomas

Trivedi, Bakula L.

Zhang, Zhang-Jin

Schmidt, Dennis E.

Ebert, Michael H.

Hewlett, William A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00497-0

TRIZAC is one of the most potent 5-HT-3 receptor antagonist reported to date, having 20-fold higher affinity than (S)-5-iodozacopride. This high affinity (K(i) 0.05 ± 0.01 nM) and a moderate apparent lipophilicity (log P(app) 2.12) makes TRIZAC a promising ligand for studying 5-HT-3 receptors.

Full text of DOI:10.1016/S0960-894X(96)00497-0

Products guided by the article

Product name:Benzoic acid, 4-(acetylamino)-5-chloro-3-iodo-2-methoxy-, methyl ester

Cas No:179872-37-8

R&D Labs maybe for 179872-37-8

SHANGHAI SYSTEAM BIOCHEM CO., LTD

website:http://www.systeambc.com

Contact:86-021-58380978

Address:Building 87，Lane 669， Dong Jing Road Shanghai,P.R.China
ChangZhou XiaQing Chemical Co., Ltd.

Contact:+86-519-88721665

Address:3# Hengluo Road, Henglin Town, Changzhou City, Jiangsu Province，China
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.

Contact:86-532-88250866

Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Beijing Cooperate Pharmaceutical Co.,Ltd

Contact:86-01060279497

Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
Shanghai Dianyang Industry Co.,ltd

Contact:+86 21 6492 4669

Address:Chejing RD, Songjiang District, Shanghai, China

Relevant to this article

Rearrangement Approaches to Cyclic Skeletons. X. Pinacol-Type Rearrangement of 2-Substituted 1-Methoxybicyclo[2.2.2]oct-5-en-2-ols into Bicyclo[3.2.1]oct-6-en-2-ones. Remarkable Substituent Effects on Predominant Migration of the Unsaturated Bridge¹

Doi:10.1246/bcsj.69.1727
(1996)
Asymmetric Photocatalytic C-H Functionalization of Toluene and Derivatives

Doi:10.1021/jacs.8b05240
(2018)
Photoelimination of Nitrogen from Diazoalkanes: Involvement of Higher Excited Singlet States in the Carbene Formation

Doi:10.1021/jacs.0c02221
(2020)
Oxidative ring cleavage of 2-nitrocycloalkanones: Synthesis and radical-induced transformations of methyl ω,ω-dihalo-ω-nitroalkanoates

Doi:10.1021/jo960488f
(1996)
Selective ligand modification of cobalt porphyrins for carbon dioxide electrolysis: Generation of a renewable H₂/CO feedstock for downstream catalytic hydrogenation

Doi:10.1016/j.ica.2020.119594
(2020)
3H-pyrrolizin-3-ones

Doi:10.1007/BF01169352
(1996)

Article Doi