Stereoselective synthesis of homochiral pyrrolidinones and cis,cis-bis-β-lactams from (+)-(1S,2S)-2-amino-1-phenylpropan-1,3-diol

Article abstract of DOI:10.1016/0040-4020(96)00462-0

The homochiral β-lactams described in the preceding paper undergone an acid catalyzed rearrangement to 4-aminopyrrolidinones 2a-e in excellent yields. A diastereoselective synthesis of cis,cis-bis-β-lactams 13 and 14 has been achieved by using imines bearing a β-lactam back bone in good yields and good to excellent selectivities.