Tetrahedron p. 8813 - 8826 (1996)
Update date:2022-08-05
Topics:
Medaer
Van Aken
Hoornaert
3,5-dichloro-2H-1,4-oxazin-2-ones and 3-chloro-2H-1,4-benzoxazin-2-ones are reacted with bifunctional reagents as sodium azide and diazocompounds to yield bi(tri)cyclic tetrazolo- or triazolo fused intermediates via an intramolecular cyclisation reaction. Conversion of these lactone inter-mediates with various nucleophiles generates new substituted 1H-tetrazoles or 1,2,3-triazoles useful for pharmacological screening and for further elaboration via the α-chloroketone substituent at N-1.
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