Tetrahedron Letters p. 6595 - 6598 (1996)
Update date:2022-08-05
Topics:
Howes, Peter D.
Smith, Paul W.
An inverse demand hetero Diels Alder strategy has been utilised for the synthesis of novel dihydropyrans as potential inhibitors of influenza virus sialidase. Cyclisation of 1-methoxy-2-acetamido ethene with 2-oxo-4-butoxycarbonylamino but-3-(Z)-enoic acid t-butyl ester in the presence of tin (IV) chloride afforded a mixture of regio- and stereochemical isomers which were further elaborated to analogues of GG167.
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Doi:10.1002/(SICI)1099-1395(199610)9:10<683::AID-POC840>3.0.CO;2-K
(1996)Doi:10.1021/jo961549c
(1996)Doi:10.1021/ja960526c
(1996)Doi:10.1016/0957-4166(96)00382-5
(1996)Doi:10.1021/jo01147a017
(1950)Doi:10.1007/BF00911367
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