An asymmetric synthesis (-)-epibatidine

DOI: 10.1016/0040-4039(96)01739-X

Source and publish data:

Tetrahedron Letters p. 7485 - 7488 (1996)

Update date:2022-09-26

Topics:

Authors:

Trost, Barry M.

Cook, Gregory R.

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Article abstract of DOI:10.1016/0040-4039(96)01739-X

A Pd catalyzed desymmetrization of cis-3,6-dibenzoyloxy-2-cyclohexene and a Pd catalyzed cross-coupling constitute key reactions in a synthesis of the non-opioid analgesic (-)-epibatidine.

Full text of DOI:10.1016/0040-4039(96)01739-X

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Product name:[(1S,3R)-3-(6-Chloro-pyridin-3-yl)-4-oxo-cyclohexyl]-carbamic acid tert-butyl ester

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