Synthesis and Sulfatase Inhibitory Activities of (E)- and (Z)-4-Hydroxytamoxifen Sulfamates

DOI: 10.1016/S0960-894X(98)00707-0

Source and publish data:

Bioorganic and medicinal chemistry letters p. 141 - 144 (1999)

Update date:2022-08-03

Topics:

Authors:

Chu, Guo-Hua

Peters, Amy

Selcer, Kyle W.

Li, Pui-Kai

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00707-0

We report the development of (E)- and (Z)-4-hydroxytamoxifen sulfamates as estrone sulfatase inhibitors, potential therapeutic agents for the treatment of breast cancer. Both compounds competitively inhibit estrone sulfatase isolated from rat liver with apparent K_i of 35.9 μM for (E)-4-hydroxytamoxifen sulfamate and an apparent K_i of >500 μM for the (Z) isomer.

Full text of DOI:10.1016/S0960-894X(98)00707-0

Products guided by the article

Product name:(E,Z)-1-[4-(benzyloxy)phenyl]-1-(4-hydroxyphenyl)-2-phenylbut-1-ene

Cas No:185223-78-3

R&D Labs maybe for 185223-78-3

AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
NanJing KaiHeng Chemical CO., LTD.

Contact:+86-25-85768391

Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA
SHANDONG AONA CHEMICAL CO.,LTD.

Contact:86-532-85762926

Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
Kono Chem Co.,Ltd

website:http://www.konochem.com

Contact:86-29-86107037

Address:No.170 West Avenue,Xi’an 710082,China
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD

website:http://www.xypharm.com/

Contact:+86-515-84383317

Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China

Relevant to this article

Nucleosides and Nucleotides. 156. Chelation-Controlled and Nonchelation-Controlled Diastereofacial Selective Thiophenol Addition Reactions at the 2′-Position of 2′-[(Alkoxycarbonyl)methylene]-2′-deoxyuridines: Conversion of (Z)-2′-[(Alkoxycarbonyl)methylene]-2′-deoxyuridines into Their (E)-Isomers

Doi:10.1021/jo9613601
(1997)
Doi:10.1021/ja01207a035
(1946)
Palladium-catalyzed intramolecular addition of trisilanes to carbon-carbon double bonds. Polyol synthesis by use of a disilanyl group as a hydroxyl equivalent

Doi:10.1016/S0040-4039(96)02075-8
(1996)
Synthesis of diether-linked cationic lipids for gene delivery

Doi:10.1016/S0960-894X(99)00187-0
(1999)
Exploration of cornea permeable calpain inhibitors as anticataract agents

Doi:10.1016/S0968-0896(02)00612-0
(2003)
Rational design of the first spherical supramolecular dendrimers self-organized in a novel thermotropic cubic liquid-crystalline phase and the determination of their shape by X-ray analysis

Doi:10.1021/ja963295i
(1997)

Article Doi