Bioorganic and medicinal chemistry letters p. 141 - 144 (1999)
Update date:2022-08-03
Topics:
Chu, Guo-Hua
Peters, Amy
Selcer, Kyle W.
Li, Pui-Kai
We report the development of (E)- and (Z)-4-hydroxytamoxifen sulfamates as estrone sulfatase inhibitors, potential therapeutic agents for the treatment of breast cancer. Both compounds competitively inhibit estrone sulfatase isolated from rat liver with apparent Ki of 35.9 μM for (E)-4-hydroxytamoxifen sulfamate and an apparent Ki of >500 μM for the (Z) isomer.
View MoreJinan Jinguilin Chemical Co.,Ltd
Contact:+86-531-81188412
Address:3rd floor of Torch Building, Huanyuan Rd, City of Jinan
ShangHai Original Economy-Trade Develop Co.,Ltd.,
Contact:86-21-68552131
Address:shanghai
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
website:http://www.chemdow.com
Contact:0086-10-82435335
Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Mollt Biochem Co., Ltd(expird)
Contact:+86-21-38682181
Address:shanghai ,china
Doi:10.1021/jo9613601
(1997)Doi:10.1021/ja01207a035
(1946)Doi:10.1016/S0040-4039(96)02075-8
(1996)Doi:10.1016/S0960-894X(99)00187-0
(1999)Doi:10.1016/S0968-0896(02)00612-0
(2003)Doi:10.1021/ja963295i
(1997)
