Synthesis of difluoromethylthio imidazole from methylthio imidazole

DOI: 10.1016/S0022-1139(96)03497-5

Source and publish data:

Journal of Fluorine Chemistry p. 159 - 162 (1996)

Update date:2022-08-04

Topics:

Authors:

Deprez, Pierre

Vevert, Jean-Paul

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Article abstract of DOI:10.1016/S0022-1139(96)03497-5

Demethylation of methylthio imidazole 1 via a Pummerer rearrangement onto the corresponding sulfoxide 2 afforded imidazole thiol 4 which was then difluoromethylated with the sodium chlorodifluoroacetate/NaI system in 71% overall yield.

Full text of DOI:10.1016/S0022-1139(96)03497-5

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