Asymmetric 1,3-Dipolar Cycloaddition: Synthesis of N-protected (4S)-4-Hydroxy L-Glutamic Acid Diester

Article abstract of DOI:10.1016/0957-4166(96)00407-7

An asymmetric synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester is described.The key feature of the synthesis is the asymmetric 1,3-dipolar cycloaddition of nitrone 4 with 5, which provides stereoselectively the isoxazolidine with the correc