182. Synthesis of fused triazoles as probes for the active site of retaining β-glycosidases: From which direction is the glycoside protonated?

Article abstract of DOI:10.1002/hlca.19960790814

The structure of the β-glycosidase inhibitors 1-7 and 10-13 suggests that protonation of O-C(1) (the glycosidic O-center) of the substrate by a carboxy group of the retaining β-glycosidases does not occur in the plane perpendicular to the ring of the glyc