Enantioselective synthesis of (2S,3S)- and (2R,3R)-pyrrolidine-2,3-dicarboxylic acids: Conformationally constrained (S)- and (R)-aspartic acid analogues

Article abstract of DOI:10.1016/S0040-4039(00)76521-X

The title compounds were prepared from the key intermediate 2 and its enantiomer at C2, derived from chiral synthons 1-(R) and 1- (S), respectively, by ethoxycarbonylation, desulfonylation and conversion to carboxylic acid.