Bioorganic and Medicinal Chemistry Letters p. 429 - 432 (1997)
Update date:2022-08-03
Topics:
Attwood, Michael R.
Conway, Elizabeth A.
Dunsdon, Rachel M.
Greening, John R.
Handa, Balraj K.
Jones, Philip S.
Jordan, Steven C.
Keech, Elizabeth
Wilson, Francis X.
Important areas of a lead peptide inhibitor of IL-8 had been previously identified. Chemical modification led to the identification of key amide bonds which allowed the replacement of the central section of the peptide with modified amino acids and spacers. This approach led to inhibitors of lower molecular weight and of increased potency.
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