Short synthetic route to retinoids through dialkylation of 3-methyl-3-sulfolene

DOI: 10.1016/S0040-4039(97)00459-0

Source and publish data:

Tetrahedron Letters p. 2585 - 2586 (1997)

Update date:2022-08-03

Topics:

Authors:

Subramanian

Padmakumar

Bhat, Sujata V.

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Article abstract of DOI:10.1016/S0040-4039(97)00459-0

The C₂₀-retinoid carbon skeleton has been synthesised through sequential alkylations of 3-methyl-3-sulfolene with bromomethyl methyl ether followed by C₁₄-aldehyde to give dialkyl sulfolene which on further desulfonylation and dehydration yielded retinol methyl ether.

Full text of DOI:10.1016/S0040-4039(97)00459-0

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