A high-yield synthesis of deoxy-2-fluoroinosine and its incorporation into oligonucleotides

DOI: 10.1016/S0040-4039(97)00540-6

Source and publish data:

Tetrahedron Letters p. 2989 - 2992 (1997)

Update date:2022-08-05

Topics:

Authors:

Adib, Abdennaji

Potier, Pierre F.

Doronina, Svetlana

Huc, Ivan

Behr, Jean-Paul

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Article abstract of DOI:10.1016/S0040-4039(97)00540-6

An improved synthesis of the deoxy-2-fluoroinosine nucleoside is described, that makes use of mild fluorination (polyvinylpyridinium polyhydrogenfluoride) and O-silyl deprotection (triethylamine trihydrofluoride) reactions. The derived 5'-dimethoxytrityl-

Full text of DOI:10.1016/S0040-4039(97)00540-6

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