Synthetic studies on maduropeptin chromophore 2. Synthesis of the madurosamine aryl amide and the C1'-C9' fragments

Article abstract of DOI:10.1016/S0040-4039(97)00724-7

A retrosynthetic analysis (Scheme 1) of maduropeptin chromophore artifact 1 defined compounds 2 and 3 as required building blocks. The construction of 2 was achieved starting from the 2,5-dimethyl derived aromatic acid 8 and the D-serine derived δ-lactone