Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization

DOI: 10.1021/jm970146h

Source and publish data:

Journal of Medicinal Chemistry p. 3049 - 3056 (1997)

Update date:2022-09-26

Topics:

Authors:

Chen, Ke

Kuo, Sheng-Chu

Hsieh, Ming-Chieh

Mauger, Anthony

Lin, Chii M.

Hamel, Ernest

Lee, Kuo-Hsiung

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Article abstract of DOI:10.1021/jm970146h

As part of our continuing search for potential anticancer drug candidates in the 2-aryl-1,8-naphthyridin-4(1H)-one series, we have synthesized two series of 3'-substituted 2-phenyl-1,8-naphthyridin-4(1H)- ones and 2-naphthyl-1,8-naphthyridin-4(1H)-ones. A

Full text of DOI:10.1021/jm970146h

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Product name:4H-Pyrido[1,2-a]pyrimidin-4-one, 6-methyl-2-(3-methylphenyl)-

Cas No:194466-63-2

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