Bioorganic and Medicinal Chemistry Letters p. 2991 - 2996 (1997)
Update date:2022-07-30
Topics:
Uoto, Kouichi
Mitsui, Ikuo
Terasawa, Hirofumi
Soga, Tsunehiko
To investigate the effect of the C-18 position of docetaxel in its cytotoxic activity, 18-modified docetaxel analogs were synthesized for the first time from the 18-brominated baccatin derivatives. All of these analogs were found to be less active than docetaxel in cytotoxic activity against four test cell lines.
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