Studies on Isoxazole and Pyrazole Formation by the Reaction of Trifluoromethyl-Substituted Anilines with Oxime and Hydrazone Dianions

Article abstract of DOI:10.1002/jhet.5570340539

5-(2-Aminophenyl)isoxazoles are obtained in good yields by the reaction of 2-(trifluoromethyl)aniline with dilithio derivatives of oximes of acetone, 3-pentanone, propiophenone, and cyclohexanone. An analogous synthesis of a substituted isoxazole from 4-(trifluoromethyl)aniline and 3-pentanone oxime and the synthesis of a substituted pyrazole from 2-(trifluoromethyl)aniline and 3-pentanone hydrazone are less efficient.