Synthesis and anti-thrombin activity of a hexasaccharide corresponding to the binding site of dermatan sulfate to heparin cofactor II

DOI: 10.1016/S0960-894X(97)10082-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2843 - 2846 (1997)

Update date:2022-08-03

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Authors:

Bourhis, Pascal

Machetto, Francoise

Duchaussoy, Philippe

Herault Herault

Mallet, Jean-Maurice

Herbert Herbert

Petitou, Maurice

Sinay, Pierre

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Article abstract of DOI:10.1016/S0960-894X(97)10082-8

A new synthetic route is described toward the hexasaccharide representing the heparin cofactor II binding region of dermatan sulfate. The anti-thrombin activity of this synthetic hexasaccharide is reported here for the first time. This compound is about two hundred times less active than dermatan sulfate itself for its ability to inhibit thrombin via heparin cofactor II.

Full text of DOI:10.1016/S0960-894X(97)10082-8

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