Synthesis of substituted 4-acetylamino-4-phenylpiperidines from the corresponding 4-piperidols under ritter reaction conditions

Article abstract of DOI:10.1007/BF02291798

The reaction of substituted 4-phenyl-4-piperidols with acetonitrile under Ritter reaction conditions leads to formation of mixtures of the corresponding 4-acetylamino-4-phenylpiperidines and 1,2,5,6-tetrahydropyridines, from which we isolated the target amides by fractional crystallization. 1997 Plenum Publishing Corporation.