2'-O-methylthiomethyl modifications in hammerhead ribozymes

Article abstract of DOI:10.1080/07328319708006114

The synthesis of all four phosphoramidites of 2'-O-methylthiomethyl ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described.

Full text of DOI:10.1080/07328319708006114

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Nucleosides and Nucleotides
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2′-O-Methyl Thiomethyl Modifications
in Hammerhead Ribozymes
Alexander Karpeisky a , Carolyn Gonzalez a , Alex B. Burgin a
Nassim Usman a & Leonid Beigelman a
,
a Departments of Organic Chemistry & Enzymology , Ribozyme
Pharmaceuticals Inc. , 2950 Wilderness Place, Boulder, CO,
80301, USA
Published online: 16 Aug 2006.
To cite this article: Alexander Karpeisky , Carolyn Gonzalez , Alex B. Burgin , Nassim Usman
& Leonid Beigelman (1997) 2′-O-Methyl Thiomethyl Modifications in Hammerhead Ribozymes,
Nucleosides and Nucleotides, 16:7-9, 955-958, DOI: 10.1080/07328319708006114
To link to this article: http://dx.doi.org/10.1080/07328319708006114
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