Asymmetric synthesis of RK-682 and its analogs, and evaluation of their protein phosphatase inhibitory activities

Article abstract of DOI:10.1016/S0040-4039(96)02029-1

We report an asymmetric synthesis of a potent tyrosine phosphatase inhibitor, RK-682 and its analogs. The absolute stereochemistry of RK-682 was determined to be (R). The inhibitory activities of RK-682 and its analogs, (R)-1a, (S)-1a, (R)-1b and (R)-1c toward various protein phosphatases (VHR, cdc25A, cdc25B, and PPI) are also reported.