New base-altered adenosine analogues: Synthesis and affinity at adenosine A1 and A(2A) receptors

Article abstract of DOI:10.1016/S0960-894X(97)10177-9

N⁶-Substituted adenosine analogues containing cyclic hydrazines or chiral hydroxy (ar)alkyl groups, designed to interact with the S2 and S3 receptor subregions, have been synthesized and their binding to the adenosine A₁ and A(2A) receptors have been investigated. Examples of both types of compounds were found to exhibit highly selective binding (K(i) in low nM range) to the rat A₁ receptor.