Synthesis and activities of bactobolin derivatives based on the alteration of the functionality at C-3 position

Article abstract of DOI:10.7164/antibiotics.51.184

Some derivatives of bactobolin were prepared from bactobolin (1) by radical reduction and formation of the fused azetidine ring. The derivatives proved less active than the parent antibiotic 1 against bacteria, indicating that dichloromethyl group at C-3 position play an important role in biological activity.