Bioorganic Chemistry p. 13 - 23 (2015)
Update date:2022-07-31
Topics:
Abdellatif, Khaled R.A.
Elshemy, Heba A.H.
Azoz, Amany A.
2-Pyrazolins 14a-l and pyrazoles 15a-l were designed as celecoxib analogs for the evaluation of their in vitro COX-1/COX-2 inhibitory activity and the in vivo anti-inflammatory activity. Compounds 14i, 15a, 15d and 15f were the most COX-2 selective derivatives (S.I. = 5.93, 6.08, 5.03 and 5.27 respectively) while the pyrazoline derivatives 14g and 14i exhibited the highest AI activity (ED50 = 190.5 and 160.1 μmol/kg po, respectively).
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