Synthesis and stabilities of the Ga(III) and In (III) chelates of a new diaminodithiol bifunctional ligand

Article abstract of DOI:10.1016/S0040-4020(98)00121-5

The synthesis of a new bifunctional ligand l-(4-carboxymethoxybenzyl)- N,N'-bis[(2-mercapto-2,2-dimethyl)ethyl]-1,2-ethylenediamine-N,N'-diacetic acid (B6SS) is described. It consists of substitution of a side-chain, a 4- carboxymethoxybenzyl group on a carbon atom of the ethylenediamine moiety of a hexadentate ligand, 6SS, which has been found to have a very high affinity for In(III). Potentiometric determination of Ga(III) and In(III) chelate stabilities of the bifunctional ligand show that the side-chain on the ligand reduces the pM values about 2-4 log values.