Synthesis of C2-symmetric dibenzyldiamino diols by double stereoselective grignard addition to (S,S)-tartraldehyde dinitrone

Article abstract of DOI:10.1016/S0040-4039(98)00330-X

A new asymmetric two-dimensional synthesis of 1,4-diamino 2,3-diols is illustrated by double addition of benzylmagnesium chloride to the bis- nitrone derived from (R,R)-tartraldehyde and reduction of the resulting dihydroxylamines.