Artemisinin tricyclic analogs: Role of a methyl group at C-5a

DOI: 10.1016/S0040-4039(98)00390-6

Source and publish data:

Tetrahedron Letters p. 2969 - 2972 (1998)

Update date:2022-08-02

Topics:

Authors:

Zouhiri, Fatima

Desmaele, Didier

D'Angelo, Jean

Riche, Claude

Gay, Frederick

Ciceron, Liliane

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Article abstract of DOI:10.1016/S0040-4039(98)00390-6

New artemisinin tricyclic analogs, bearing a methyl group at C-5a were synthetized through ozonation of vinylsilanes. Presence of such a substituent was detrimental to the antimalarial activity of these trioxanes, thus reinforcing the hypothesis that tight hemin-trioxane complexes are involved in the activation phase of these compounds.

Full text of DOI:10.1016/S0040-4039(98)00390-6

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