Asymmetric total synthesis of (-)-epibatidine

DOI: 10.1016/S0040-4039(98)00803-X

Source and publish data:

Tetrahedron Letters p. 4513 - 4516 (1998)

Update date:2022-08-05

Topics:

Authors:

Aoyagi, Sakae

Tanaka, Ryuta

Naruse, Masaichi

Kibayashi, Chihiro

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Article abstract of DOI:10.1016/S0040-4039(98)00803-X

An enantioselective approach to (-)-epibatidine based on asymmetric hetero Diels-Alder cycloaddition with an N-acylnitroso dienophile bearing 8- (2-naphthyl)menthol as a chiral source, wherein π-π stacking interaction between the naphthyl and nitrosocarbonyl groups may contribute to facial control, is described.

Full text of DOI:10.1016/S0040-4039(98)00803-X

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