Epoxide opening with acetylide for synthesis of epothilone A C7-21 segment

DOI: 10.1016/S0040-4039(98)01060-0

Source and publish data:

Tetrahedron Letters p. 5261 - 5264 (1998)

Update date:2022-08-05

Topics:

Authors:

Liu, Zhi-Yu

Yu, Chen-Zhi

Wang, Rui-Fang

Li, Gang

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Article abstract of DOI:10.1016/S0040-4039(98)01060-0

A Chiral synthesis of epothilone A C^7-21 segment 2 is described using epoxide opening with acetylide for the construction of the C^12-13 cis double bond and a modified Wittig reaction for introduction of the thiazole side chain.

Full text of DOI:10.1016/S0040-4039(98)01060-0

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